BMB Reports : eISSN 1976-670X

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Fig. 3. TOMM20 is overexpression in colorectal cancer tissues and Knockdown of TOMM20 suppressed CRC tumor growth in vivo. (A) Analyses of TOMM20 mRNA expression level in GEO data (***P < 0.001). (B) Relative expression of TOMM20 mRNA in 25 CRC patients as assessed by qRT-PCR analysis. The P-value was calculated by the Mann-Whitney test (*P < 0.05). Western blot analysis of TOMM20 was applied in 16 CRC tumor and matching normal tissues. (C) Representative Images of TOMM20 detected by IHC in CRC tissues and the non-tumor tissue. Scale bar = 200 μm. (D) Intratumoral injection of siTOMM20led to stunting of tumor growth (n = 5). (E) Tumor weight at 21 days after siRNA injection (F) TOMM20 and Ki67 expression characterized by immunohistochemical staining of xenografts tumors. Scale bar: 100 μm.
BMB Reports 2019;52:712~717
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