BMB Reports : eISSN 1976-670X

Download original image
Fig. 3. Role of mTOR signalling pathway during protein translation. Translation initiation at the brain is regulated by various translation initiation factors including eIF3, eIF4A, eIF4B, eIF4G, and cap binding protein eIF4E. Mechanism of mTOR is regulated by either 4E-BP or P70S6K. 4E-BP binds to eIF4E and inhibits the initiation of translation while S6 kinase from P70S6K binds to the 40S ribosomal subunit and leads to truncated protein synthesis in affected regions. Altered translation leads to development of adverse characteristics in the neuronal phenotype of idiopathic autism individuals.
BMB Reports 2019;52:424~433
© BMB Rep.