BMB Reports : eISSN 1976-670X

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Fig. 1. Schematic representation of various molecular inhibitors and stimulators in mTOR signalling pathway. PTEN and NF1 could inhibit the activation of AKT. AKT when mutated could inhibit the activation of TSC 1 and TSC 2 that are precursors of mTORC1. FMRP inhibition could lead to deactivation of mTORC2. When stimulated, mTORC1 is involved in various cellular processes including microtubule organisation, autophagy, lipid biosynthesis, RNA biosynthesis, and protein synthesis using precursors of CLIP-170, ULK1, Lipin-1, TFEB, and P70S6K, respectively. Stimulation of mTORC2 leads to proper cytoskeletal organisation through RAC, Rho, and PKC. Cell survival is achieved through SGK1.
BMB Reports 2019;52:424~433 https://doi.org/10.5483/BMBRep.2019.52.7.137
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