BMB Reports : eISSN 1976-670X

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Fig. 3. Transcriptional memory in immune cells. (A) Monocyte exposed to immune stimulation such as lipopolysaccharide (LPS) or beta-glucan exhibits different levels of H3K4me1, H3K4me3 and H3K27ac globally even after differentiation into macrophage. (B) Effector T cell exhibits transcriptional memory upon 2nd stimulation. At that time, the chromosomal allelic pairing and Pol II pausing are occurred at locus of the related genes, which lead to bi-allelic RNA expression and finally rapid gene expression.
BMB Reports 2019;52:127~132
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