BMB Reports : eISSN 1976-670X

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Fig. 1. Schematic diagram of a novel, proteasome-dependent mode of RIP3 degradation mediated by an E3 ubiquitin ligase, PELI1. Phosphorylation of RIP3 on T182 leads to interaction with the FHA domain of PELI1 and PELI1-mediated K48-linked polyubiquitylation of RIP3 at K363 leads to its proteasome-dependent degradation. Regulation of activated RIP3 by PELI1 provides a homeostatic mechanism to prevent aberrant cell death and minimize necroptotic pathology.
BMB Reports 2018;51:484~485
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