BMB Reports : eISSN 1976-670X

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Fig. 1. Graphic summary of the study. Hyperlipidemic environment triggers IL-27 secretion by dendritic cells in a TLR4- and LXR-dependent manner, which then stimulates the differentiation of CXCR3+ TFH cells. These CXCR3+ TFH cells induce germinal center reactions and the production of pathogenic IgG2c autoantibodies to aggravate autoimmune lupus in mice.
BMB Reports 2018;51:371~372
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