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Fig. 1. Mitochondrial surveillance and mitophagy contribute to immunity. Pyoverdine, a siderophore produced by Pseudomonas aeruginosa, binds and removes iron in hosts, triggering mitochondrial stress. Host mitochondrial surveillance mechanism detects mitochondrial stress and activates ESRE (Ethanol and Stress Response Element) gene network. The induction of ESRE-containing genes increases immunity. Reduced mitochondrial iron levels also induce mitophagy that enhances immunity, acting through autophagy machinery proteins, including PTEN-induced putative kinase 1 (PINK1), Beclin 1, and microtubule-associated protein light chain 3 (LC3).
BMB Reports 2018;51:274~279 https://doi.org/10.5483/BMBRep.2018.51.6.111
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