BMB Reports : eISSN 1976-670X

Download original image
Fig. 2. Summary of signaling pathways that regulate interactions between YAP and its partners. SMADs activated by TGF-β translocate into the nucleus and bind to YAP, thus promoting the expression of target gene. TEAD is a representative transcription factor that binds to YAP and promotes cell proliferation. YAP is inactivated by LATS kinase which is activated by MST or inactivated by TRIO-RAC1 signaling. In DNA damage, YAP phosphorylated by c-ABL binds to p73 in the nucleus and promotes apoptosis. YAP-ERBB4 activated by NRG1 regulates cell growth by promoting the expression of target genes, including CTGF, CYR61, and ANKRD1.
BMB Reports 2018;51:126~133
© BMB Rep.