BMB Reports : eISSN 1976-670X

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Fig. 1. The Integrated Stress Response. There are four known stress-responsive eIF2α kinases that can impact global translation: PERK, GCN2, PKR and HRI. Phosphorylation of eIF2α results in the disassembly of the eIF2 complex, and thus reduced availability of initiator methionine (Met-tRNAiMet). While this attenuates translation of most transcripts, a small subset of stress-responsive transcripts such as ATF4 is paradoxically synthesized. ATF4 subsequently induces the transcription of various stress response genes.
BMB Reports 2017;50:539~545
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