BMB Reports : eISSN 1976-670X

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Fig. 1. Protein phosphatase 2A is comprised of three components: the catalytic C, the scaffolding A, and the regulatory B subunits. Structural and bioinformatics analysis unveiled that B56, one of the B subunits, binds to its target either through the central region or the C-terminal edge of the pseudo heat domain. The central region recognize B56 targets that contain LxxIxE motif (, ), whereas the C-terminal end region binds to distinct type of target such as Shugoshin (). Number of B56 genes in yeast, fungi, protist, plants, and human is shown. A single B56 gene exists in Dictyostelium discoideum. PTPA and PTPB is competing with the regulatory B subunits to associate with the AC core dimer (i). TorC1/TAP42 inhibits the PP2A catalytic activity (ii). Src tyrosine kinase phosphorylates and inhibits the catalytic PP2A subunit (iii). TorC2/PKA signaling axis activates B56/PP2A (iv) whereas Protein Kinase C and ERK1/2 phosphorylate and inhibit B56 (v and vi).
BMB Reports 2017;50:437~444 https://doi.org/10.5483/BMBRep.2017.50.9.091
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