BMB Reports : eISSN 1976-670X

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Fig. 2. Sub-cellular localizations and functions of PDI proteins related to cancer. PDI proteins located at the cell surface are involved in the cell adhesion/migration via activation of metallo-proteases and integrins. In the ER, PDI proteins are required for UPR which determines the survival/death of cells via ATF6α activation or ERAD/autophagy induction. Although the localization of PDI in the cytosol and/or nucleus are not clearly understood, PDI proteins control apoptosis via caspase activation and Hsp27 induction. PDI proteins also play a role in the regulation of the epithelial-mesenchymal transition (EMT). See text for more details.
BMB Reports 2017;50:401~410
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