BMB Reports : eISSN 1976-670X

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Fig. 1. Proposed reaction mechanisms of non-canonical targets in the regulation of miRNA stability in human Ago proteins. miRNAs bind to non-canonical targets with low affinities because of mismatches in the seed region. Upon an extensive 3′ pairing between miRNAs and their targets, the 3′ ends of miRNAs are released from the PAZ domain, and this, in turn, leads to destabilization of miRNAs from Ago proteins.
BMB Reports 2017;50:158~159
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