BMB Reports : eISSN 1976-670X

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Fig. 1. Schematic representation of the cellular mechanisms of spike-frequency adaptation via ANO2 channel. The repetitive neuronal firing increases the intracellular Ca2+ level derived from influx through voltage-gated Ca2+ channels (VGCCs) and release from endoplasmic reticulum (ER)., which in turn activates ANO2 channels near the cell body of TC neurons. This inward Cl flow due to low intracellular Cl concentration generates hyperpolarization of neurons and modulate the spike-frequency adaptation via the shunting effect.
BMB Reports 2017;50:109~110
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