BMB Reports : eISSN 1976-670X

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Fig. 1. Yap/Taz forms a critical positive feedback loop with Notch signaling to promote liver enlargement and turmorigenesis (red). Breaking this positive feedback-loop led to reduced hepatomegaly and tumor progression. The inhibitory role of Wnt/β-catenin in the liver tumor, caused by the viscous positive feedback, is at least in part through the DP1-mediated inhibition of Notch signaling (blue).
BMB Reports 2017;50:1~2
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