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Article Info.
2012.06.30; 45(6) pp. 323~330
Title

Glycoscience aids in biomarker discovery

Authors

Serenus Hua1,2 & Hyun Joo An1,2,*  

Institutions

1Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, 2Cancer Research Institute, Chungnam National University, Daejeon 301-721, Korea  

Abstract

The glycome consists of all glycans (or carbohydrates) within a
biological system, and modulates a wide range of important biological
activities, from protein folding to cellular communications.
The mining of the glycome for disease markers represents
a new paradigm for biomarker discovery; however, this effort
is severely complicated by the vast complexity and structural
diversity of glycans. This review summarizes recent developments
in analytical technology and methodology as applied to
the fields of glycomics and glycoproteomics. Mass spectrometric
strategies for glycan compositional profiling are described, as are
potential refinements which allow structure-specific profiling.
Analytical methods that can discern protein glycosylation at a
specific site of modification are also discussed in detail.
Biomarker discovery applications are shown at each level of
analysis, highlighting the key role that glycoscience can play in
helping scientists understand disease biology.  

Keywords

Biomarker, Glycomics, Glycoproteomics, Glycosylation, Mass spectrometry